Journal: International Journal of Molecular Sciences
Article Title: Circulatory Indicators of Lipid Peroxidation, the Driver of Ferroptosis, Reflect Differences between Relapsing–Remitting and Progressive Multiple Sclerosis
doi: 10.3390/ijms252011024
Figure Lengend Snippet: Molecular parameters in patients with RRMS and PMS: ( a ) Malondialdehyde (MDA); ( b ) 4-Hydroxynonenal (4-HNE); ( c ) Hexanoyl-lys adduct (HEL); ( d ) Glutathione peroxidase 4 (GPX4); ( e ) Total glutathione, GSH + GSSG; ( f ) Reduced glutathione (GSH); ( g ) Oxidized glutathione (GSSG); ( h ) Iron; ( i ) Transferrin; ( j ) Ferritin. RRMS—relapsing–remitting multiple sclerosis; PMS—progressive multiple sclerosis; values of parameters are presented with median and range (minimum–maximum); p -values (Mann–Whitney U test) < 0.05 are considered statistically significant: * p < 0.05, ** p < 0.01.
Article Snippet: FineTest ® kits for enzyme-linked immunosorbent assay (ELISA): Human MDA (Malondialdehyde) ELISA Kit, Human 4-HNE (4-Hydroxynonenal) ELISA Kit and Human GPX4 (Phospholipid hydroperoxide glutathione peroxidase) ELISA Kit (Wuhan Fine Biotech Co., Ltd., Wuhan, China), were used for quantification of MDA, 4-HNE, and GPX4, respectively, in plasma samples of all 222 patients.
Techniques: MANN-WHITNEY